EVEROTAS 10MG

DESCRIPTION
Everotas 10mg belongs to anti-neoplastic agent, it comes under mTOR kinase inhibitor (single transduction inhibitor). Everotas 10mg is an immunosuppressive macrolide.

USED FOR
Breast cancer 
patient who fails to respond to the tablet letrozole or anastrozole therapy would be treated with Everotas. Everotas 10mg is used in an advanced stage of breast cancer. 

Neuroendocrine tumors 
Everotas 10mg involved in the treatment of some neuroendocrine tumors like pancreatic, gastrointestinal or lung cancer. 

Renal cell cancer 
patient treating with Everotas 10mg after the failure of treatment with Sunitinib or Sorafenib.
Everotas 10mg also used in the condition of; Heart, liver, kidney transplantation
Waldenström macroglobulinemia
Other carcinoid tumors.

MECHANISM OF ACTION
Everotas is the prohibition of mammalian target of rapamycin (mTOR), a serine-threonine kinase.
Everotas bind with intercellular protein (FKBP-12), leads to inhibitory complex formation with mTOR complex 1 (mTORC1) this leads to inhibition of mTOR kinase activity.
Everotas decreased the effect of S6 ribosomal protein kinase (S6K1) and eukaryotic elongation factor 4E binding protein (4E-BP1) which are essential for protein synthesis.
mTOR inhibited by Everotas lead to reduce cell multiplication and angiogenesis.

DOSAGE AND ADMINISTRATION
The recommended dose of the Tablet Everotas is 10mg should be taken as a single dose in all carcinogenic condition, except organ transplantation.
Organ transplant: 0.75mg orally twice daily.
Brain/intracranial tumor: 4.5mg/m2 orally once a day (for both pediatric and adult dose)
Hepatic impairment: dose reduced to 7.5mg once daily followed by 5mg as a single dose.
Everotas is in tablet form. It should be administered orally at the same time every day.
Everotas should be taken with or without food.
Everotas tablets should not crush or break.

PRECAUTIONS
Before going to start the Everotas 10mg therapy, doctor should consult with patient whether they are taking any medicines like:
Aspirin
Any kind of immunization or vaccine
Care should be taken in pregnancy condition.

PREGNANCY
Everotas 10mg should not use in pregnancy conditions and for breastfeeding mothers.
Pregnancy category: C
Everotas 10mg causes harm or any malformation in unborn babies.

STORAGE
Everotas 10mg should be stored in room temperature
Keep away from moisture, heat, and light

FOR MORE INFORMATION:

EMAIL:
info@blueberrypharma.com

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