記事一覧
Practical Reactions / Bond Formation
Three-component Condensation / MAC Reagent
α -Acetoxyacetic Acid Methyl Esters; General Procedures Method A (21a-e)
H-MAC-Ac (16; 29.8 mg, 0.24 mmol, 1.2 equiv) was added to a solution of 20 (0.20
Practical Reactions / FGI
B(OH)2, Bpin → NH2
1
Add boronic acid (0.5 mmol, 1.0 equiv.) and N-Boc-Otosylhydroxylamine (1.5 equiv.) in 1, 2-dichloroethane (1 mL) to a round-bottom flask equipped with a magnetic stirring bar at
Practical Reactions / Bond Formation
DMF-DMA / dimethylaminomethylation
A solution of 1-[3-(4-benzoyl-2-methyl-piperazin-1-sulfonyl)-1H-pyrrolo[2,3-c]pyridin-7-yl]-ethanone (0.78 g, 1.8 mmol) and dimethylformamide dimetylacetal (6.3 mL)
Practical Reactions / Bond Formation
Mitsunobu Reaction / Tsunoda Reagent
To a solution of 2-(1,3-dioxan-2-yl)ethylsulfonamide (295.3 mg, 1.5 mmol) and 2-octen-1-ol (155 μL, 1.0 mmol) in dry toluene (5 mL) was added CMBP (0.4 mL, 1.5 mm
Practical Reactions / Reduction
Borane Reduction
To a solution of 2-((2-methoxyethyl){[trans-(1S,2S)-2-methylcyclopropyl]methyl}amino)-6-[methyl(methylsulfonyl)amino]isonicotinic acid (202 mg, 0.544 mmol) in THF (3 ml) at 0 °C was
Practical Reactions / FGI
Curtius Rearrangement
A mixture containing 4-(methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid (100 mg, 0.471mmol), diphenyl phosphoryl azide (130 mg, 0.471 mmol) and Et3N (0.07 mL, 0.500 mmol)
Practical Reactions / Oxidation
Dess-Martin Oxidation
Preparation of (3as, 6S, 6aS)-(9H-fluoren-9-yl)methyl 6-tert-butoxy-3- oxotetrahydro-2H-furo[3,2-b]pyrrole-4(5H)-carboxylate (4c).
Alcohol (4b) (70 mg, 0.165 mmol) was dissolve
Practical Reactions / Bond Formation
Suzuki-Miyaura Cross Coupling
A screw-top test tube equipped with a magnetic stir bar was charged with 6a or 7a (0.02 mmol, 2 mol %), arylboronic acid (1.50 mmol, 1.50 equiv), and aryl halide (if sol